Copyright © 2007, European Society of Cardiology
CD36 and macrophages in atherosclerosis
a Cardiovascular Division, King's College, London, UK
b Thrombosis Research Institute, London, UK
c INSERM Unit 689, Hôpital Lariboisière, Paris, France
* Corresponding author. Cardiovascular Division, King's College London, Waterloo Campus, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. Tel.: +44 20 7848 4281; fax: +44 20 7848 3743. sophie.collot{at}kcl.ac.uk
CD36 is a multi-ligand scavenger receptor present on the surface of a number of cells such as platelets, monocytes/macrophages, endothelial and smooth muscle cells. Monocyte/macrophage CD36 has been shown to play a critical role in the development of atherosclerotic lesions by its capacity to bind and endocytose oxidized low density lipoproteins (OxLDL), and it is implicated in the formation of foam cells. However, the significance of CD36 in atherosclerosis has recently been called into question by different studies, and therefore its exact role still needs to be clarified. The aim of this article is to carefully review the importance of CD36 as an essential component in the pathogenesis of atherosclerosis.
KEYWORDS CD36; Vascular; Monocyte/macrophages; OxLDL; Atherosclerosis
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J.-h. Xue, Z. Yuan, Y. Wu, Y. Liu, Y. Zhao, W.-p. Zhang, Y.-l. Tian, W.-m. Liu, Y. Liu, and C. Kishimoto High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance Cardiovasc Res, January 4, 2010; (2010) cvp388v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Xanthis, A. Hatzitolios, S. Fidani, C. Befani, G. Giannakoulas, and G. Koliakos Receptor of Advanced Glycation End Products (RAGE) Positively Regulates CD36 Expression and Reactive Oxygen Species Production in Human Monocytes in Diabetes Angiology, December 1, 2009; 60(6): 772 - 779. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Amoruso, C. Bardelli, L. G. Fresu, A. Palma, M. Vidali, V. Ferrero, F. Ribichini, C. Vassanelli, and S. Brunelleschi Enhanced Peroxisome Proliferator-Activated Receptor-{gamma} Expression in Monocyte/Macrophages from Coronary Artery Disease Patients and Possible Gender Differences J. Pharmacol. Exp. Ther., November 1, 2009; 331(2): 531 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Ramji Growth hormone-releasing peptides, CD36, and stimulation of cholesterol efflux: cyclooxygenase-2 is the link Cardiovasc Res, August 1, 2009; 83(3): 419 - 420. [Full Text] [PDF]
|
|
|
|
|
|
C. Erridge CD36: promotion from scavenger receptor to mediator of migration? Cardiovasc Res, July 1, 2009; 83(1): 5 - 6. [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Reiss, D. W. Wan, K. Anwar, J. T. Merrill, P. A. Wirkowski, N. Shah, B. N. Cronstein, E. S. L. Chan, and S. E. Carsons A BRIEF COMMUNICATION: Enhanced CD36 Scavenger Receptor Expression in THP-1 Human Monocytes in the Presence of Lupus Plasma: Linking Autoimmunity and Atherosclerosis Exp Biol Med, March 1, 2009; 234(3): 354 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Handberg, M. Skjelland, A. E. Michelsen, E. L. Sagen, K. Krohg-Sorensen, D. Russell, A. Dahl, T. Ueland, E. Oie, P. Aukrust, et al. Soluble CD36 in Plasma Is Increased in Patients With Symptomatic Atherosclerotic Carotid Plaques and Is Related to Plaque Instability Stroke, November 1, 2008; 39(11): 3092 - 3095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Jin, T. S. Ha, and D. P. Smith SNMP is a signaling component required for pheromone sensitivity in Drosophila PNAS, August 5, 2008; 105(31): 10996 - 11001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-M. Brand-Herrmann Where Do We Go for Atherothrombotic Disease Genetics? Stroke, April 1, 2008; 39(4): 1070 - 1075. [Full Text] [PDF]
|
|
|
|
|
|
D. Siegel-Axel, K. Daub, P. Seizer, S. Lindemann, and M. Gawaz Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis Cardiovasc Res, April 1, 2008; 78(1): 8 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Collot-Teixeira, F. Delorenzo, and J. L. McGregor Scavenger Receptor A and CD36 Are Implicated in Mediating Platelet Activation Induced by Oxidized Low- Density Lipoproteins Arterioscler Thromb Vasc Biol, December 1, 2007; 27(12): 2491 - 2492. [Full Text] [PDF]
|
|